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Copyrights © 2008 , Sevas Educational Society, All rights Reserved |
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A possible role of repair proteins BRCA1 and DNA-PK in the processing of oxidative DNA damage |
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Special Contributions
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Alexandros G Georgakilas * |
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Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858 USA |
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Received: 6 June 2008, Accepted: 10 August 2008 Published online: 18 August 2008 |
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Abstract |
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BRCA1 and DNA-PK are two significant multifunctional proteins involved primarily in the processing of double strand breaks (DSBs). BRCA1 participates actively in homologous recombination (HR) while DNA-PK in non-homologous end joining (NHEJ). In this mini review, we discuss all recent evidence for a possible involvement of these repair proteins also in the processing of oxidatively-induced DNA damage. |
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| *Tel: 001-252 3285446, Fax: 001-252 3284178 |
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| Volume 1, Issue 1, August 2008, Page No. 09-10 |
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