Study of oxidative stress, homocysteine, copper & zinc in nephrotic syndrome: therapy with antioxidants, minerals and B-complex vitamins

J Biochem Tech

Volume 1, Issue 4, August 2009, Page No. 104-107

Study of oxidative stress, homocysteine, copper & zinc in nephrotic syndrome: therapy with antioxidants, minerals and B-complex vitamins

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Jyoti Dwivedi

, Purnima Dey Sarkar

Dept. of Biochemistry, S.S. Medical College Rewa, Madhya Pradesh, India, Pin-486001

Received: 26 July 2009 / Received in revised form: 23 August 2009, Accepted: 15 September 2009, Published online: 22 September 2009

Abstract

Oxidative damage has been proposed as one of the possible
mechanism involved in the nephrotic syndrome. Strengthening the
defense system by antioxidants may provide protection against
oxidative damage. Therefore, this study was carried out to
investigate oxidant and antioxidant status with copper, zinc and
homocysteine in nephrotic syndrome patients and the effect of
antioxidants, minerals and B-complex vitamins on oxidant and
antioxidant status. The blood samples were analyzed for quantitation
of malondialdehyde as index of lipid peroxide, vitamin C, total
antioxidant capacity, copper, zinc, and homocysteine. Significantly
increased levels of serum lipid peroxide, homocysteine and
decreased levels of serum total antioxidant capacity, copper, zinc
and plasma vitamin C were noticed in the patients with nephrotic
syndrome as compared to control subjects. However, significant
reduction in lipid peroxide, homocysteine and improvement in
vitamin C, total antioxidant capacity, copper, and zinc activity were
observed after treatment of antioxidants and minerals with Bcomplex
vitamins.

Keywords: Nephrotic syndrome (NS), Total antioxidant capacity
(TAC), Homocysteine (HCY), Malondialdehyde (MDA), Vitamin C
(Vit C), Copper (Cu), Zinc (Zn)

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J Biochem Tech

Volume 1, Issue 4, August 2009, Page No.104-107




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