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Copyrights © 2008 , Sevas Educational Society, All rights Reserved |
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Supercritical fluids technology in bioprocess industries: A review |
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Email Article |
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Tell a friend about J Biochem Tech |
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More Articles
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Kianoush Khosravi Darani , Mohammad Reza Mozafari |
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Department of Food Technology Research, National Nutrition and
Food Technology Research Institute, Shaheed Beheshti Medical
University, P. O. Box: 19395-4741, Tehran, I. R. Iran |
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Received: 10 October 2009 / Received in revised form: 30 January 2010, Accepted: 30 January 2010, Published online: 10 March 2010 © Sevas Educational Society 2008 |
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Abstract |
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This article reviews the fundamentals of supercritical fluid (SCF) science and moves on to the biotechnological applications of them e.g. removal of biostatic agents from fermentation broths, SCF disruption of microorganisms, destruction of industrial waste, the gas-antisolvent crystallization and micron-size particle formation. Also gaining ground is enzymatic catalysis in supercritical carbon dioxide (SC-CO2), which offers the possibility of integrated synthesis product recovery processes. The paper is structured as follows: first, the effects of dense SC-CO2 on the extraction of biomaterials and disruption of cells are thoroughly reported and discussed. Then the application of SC-CO2 in particle formation and modifications of biopolymers and enzymes are described. In general, the article is focused on potential bio-industrial applications and future research needs of the SCF technology. |
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Keywords: Biotechnology, Supercritical Fluids (SCF), disruption, inactivation, extraction, downstream, particle formation |
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| Volume 2, Issue 1, Dec 2009, Page No. 144-152 |
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