Inhibitory effect of dates-extract on a-Amylase and ß-glucosidase enzymes relevant to non-insulin dependent diabetes mellitus

J Biochem Tech

Volume 2, Issue 2, Apr 2010, Page No. 158-160

Inhibitory effect of dates-extract on α-Amylase and β-glucosidase enzymes relevant to non-insulin dependent diabetes mellitus

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Sulaiman Al-Zuhair

, Ali Dowaidar and Hassan Kamal

*Department of Chemical and Petroleum Engineering, UAE University, Al-Ain, United Arab Emirates

Received: 4 April 2010 / Received in revised form: 9 June 2010, Accepted: 9 June 2010, Published online: 7 July 2010

Abstract

α-Amylase and β-glucosidase are key enzymes involved in
carbohydrates breakdown and intestinal absorption, respectively.
Inhibition of these enzymes hinders blood glucose level increase
after a carbohydrate diet and can be an important strategy in the
management of non-insulin-dependent diabetes mellitus (NIDDM).
A main drawback of currently used inhibitors is their side effects
such as abdominal distention, flatulence, meteorism and diarrhea,
caused by excessive inhibition of pancreatic α-amylase resulting in
abnormal bacterial fermentation of undigested carbohydrates in the
colon. Natural inhibitors from plants have shown lower inhibitory
effect against α-amylase activity and a stronger inhibitory activity
against α-glucosidase and can be used as effective therapy for
NIDDM with minimal side effects. In this work dates-extract (DE)
inhibitory effect on α-amylase and α-glucosidase has been assessed.
The inhibition percentages on α-amylase and α-glucosidase were in
the range of 6-24% and 54%, respectively. The results clearly show
the NIDDM treatment potential of DE.

Keywords: Diabetes, dates-extract, α-amylase, α-glucosidase,
enzyme inhibition

*Tel: 0097 13713363; Fax: 0097 137624262

J Biochem Tech

Volume 2, Issue 2, Apr 2010, Page No. 158-160




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