Effect of ginger on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced experimental colon carcinogenesis

J Biochem Tech

Volume 2, Issue 2, Apr 2010, Page No. 161-167

Effect of ginger on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced experimental colon carcinogenesis

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V Manju

, N Nalini

*Department of Biochemistry, Periyar University, Salem- 11, Tamilnadu, India.

Received: 11 January 2010/ Received in revised form: 18 March 2010, Accepted: 19 March 2010, Published online: 07 July 2010

Abstract

The prevalence of colon cancer has rapidly risen during the last
decade. In this study we have evaluated the chemopreventive efficacy
of ginger in 1,2-dimethyl hydrazine (DMH) induced colon
carcinogenesis. Rats were given a weekly subcutaneous injection of
DMH at a dose of 20mg/kg body weight for 15 weeks. Ginger
(50mg/kg body weight/day) was given at the initiation and also at the
post-initiation stages of carcinogenesis to DMH treated rats every day.
The animals were sacrificed at the end of 30 weeks. Colon cancer
incidence was 100% in DMH treated rats. The incidence of cancer as
well as the number of tumours in the colon was significantly reduced
on supplementing ginger to DMH treated rats. The levels of lipid
peroxidation and the activities of the enzymic antioxidants such as
superoxide dismutase and catalase in the colon and intestines were
significantly decreased whereas the activities of glutathione and its
dependent enzymes such as, glutathione peroxidase, glutathione-Stransferase
and glutathione reductase and the levels of non-enzymic
antioxidants such as vitamin C and vitamin E were significantly
elevated in DMH treated rats as compared to control animals. Ginger
supplementation to DMH treated rats inhibited colon carcinogenesis,
as evidenced by the significantly decreased number and incidence of
tumours. In addition ginger optimized tissue lipid peroxidation and
antioxidant status in DMH treated rats.

Keywords: Antioxidants, 1, 2-dimethyl hydrazine, ginger, lipid peroxidation

*Tel: 0091 9940247576, Fax: 0091 427 2345565,

J Biochem Tech

Volume 2, Issue 2, Apr 2010, Page No. 161-167




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